Associate Professor Colin Jackson

Associate Professor, Research School of Chemistry
ANU College of Physical & Mathematical Sciences

Dr Colin Jackson has held research positions at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and was a visiting research fellow at the Weizmann Institute of Science (Rehovot, Israel) and a Marie Curie Research Fellow at the Institut de Biologie Structurale (Grenoble, France), before his appointment as a Senior Lecturer at the Research School of Chemistry.

 

Groups

  • Ney, B, Ahmed, H, Carere, C et al. 2017, 'The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria', The International Society of Microbial Ecology, vol. 11, no. 1, pp. 125-137pp.
  • Ney, B*, Ahmed, FH*, Carere, C et al 2017, 'The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria', The International Society of Microbial Ecology, vol. 11, no. 1, pp. 125-137pp. [*: joint first authors]
  • Mabbitt, P, Correy, G, Fraser, N et al. 2016, 'Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency', Biochemistry, vol. 55, no. 9, pp. 1408-1417.
  • Greening, C, Biswas, A, Carere, C et al 2016, 'Genomic and metagenomic surveys of hydrogenase distribution indicate H-2 is a widely utilised energy source for microbial growth and survival', The International Society of Microbial Ecology, vol. 10, no. 3, pp. 761-777pp.
  • Fraser, N, Liu, J, Mabbitt, P et al 2016, 'Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability', Journal of Molecular Biology, vol. 428, no. 11, pp. 2359-2371.
  • Horgan, C, Han, Y, Trueman, H et al 2016, 'Phosphorescent oxygen-sensing and singlet oxygen production by a biosynthetic silk', RSC Advances, vol. 6, no. 46, pp. 39530-39533.
  • Correy, G, Carr, P, Meirelles Betancur, T et al. 2016, 'Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography', Structure, vol. 24, no. 6, pp. 977-987.
  • Chan, K, Mabbitt, P, Phua, S et al. 2016, 'Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 31, pp. E4567-E4576.
  • Greening, C, Ahmed, H, Mohamed, A et al. 2016, 'Physiology, Biochemistry, and Applications of F-420- and F-o-Dependent Redox Reactions', Microbiology and Molecular Biology Reviews, vol. 80, no. 2, pp. 451-493.
  • Mohamed, A, Ahmed, H, Sundaram, A et al. 2016, 'Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis', Molecular BioSystems, vol. 12, no. 4, pp. 1110-1113.
  • Clifton, B & Jackson, C 2016, 'Ancestral Protein Reconstruction Yields Insights into Adaptive Evolution of Binding Specificity in Solute-Binding Proteins', Cell Chemical Biology, vol. 23, no. 2, pp. 236-245.
  • Greening, C*, Ahmed, FH*, Mohamed, AE et al 2016, 'Physiology, biochemistry, and applications of F420- and Fo-dependent redox reactions', Microbiology and Molecular Biology Reviews, vol. 80, no. 2, pp. 451-493. [*: joint first authors]
  • Mohamed, AE, Ahmed, FH, Arulmozhiraja, S et al 2016, 'Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis', Molecular BioSystems, vol. 12, no. 4, pp. 1110-1113.
  • Sugrue, E, Fraser, N, Hopkins, D et al. 2015, 'Evolutionary Expansion of the Amidohydrolase Superfamily in Bacteria in Response to the Synthetic Compounds Molinate and Diuron', Applied and Environmental Microbiology, vol. 81, no. 7, pp. 2612-2624.
  • Kaltenbach, M, Jackson, C, Campbell, E et al 2015, 'Reverse evolution leads to genotypic incompatibility despite functional and active site convergence', eLife, vol. 4, pp. 1-20.
  • Van Benschoten, A, Afonine, P, Terwilliger, T et al 2015, 'Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles', Acta Crystallographica Section D: Biological Crystallography, vol. 71, no. Pt 8, pp. 1657-1667.
  • Whitfield, J, Zhang, W, Herde, M et al 2015, 'Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction', Protein Science, vol. 24, no. 9, pp. 1412-1422.
  • Riley, B, Broendum, S, Reboul, C et al 2015, 'Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC', PLOS ONE (Public Library of Science), vol. 10, no. 10, pp. e0140219-e0140219.
  • Banwell, M, Buckler, J, Jackson, C et al 2015, 'Devising New Syntheses of the Alkaloid Galanthamine, a Potent and Clinically Deployed Inhibitor of Acetylcholine Esterase', Strategies and Tactics in Organic Synthesis, vol. 11, pp. 29-50.
  • Ahmed, FH, Carr, P, Lee, B et al 2015, 'Sequence-Structure-Function Classification of a Catalytically Diverse Oxidoreductase Superfamily in Mycobacteria', Journal of Molecular Biology, vol. 427, no. 22, pp. 3554-3571.
  • Jackson, C, Carville, A, Ward, J et al 2014, 'Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning', Toxicology, vol. 317, pp. 1-5.
  • Naqvi, T, Warden, A, French, N et al. 2014, 'A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis', PLOS ONE (Public Library of Science), vol. 9, no. 4, pp. e94177-e94177.
  • Jackson, C, Coppin, C, Carr, P et al. 2014, '300-Fold Increase in Production of the Zn2+ -Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization', Applied and Environmental Microbiology, vol. 80, no. 13, pp. 4003-4011.
  • Lan, P, Jackson, C, Banwell, M et al 2014, 'Synthesis of a D-ring isomer of galanthamine via a radical-based Smiles rearrangement reaction', Journal of Organic Chemistry, vol. 79, no. 14, pp. 6759-6764.
  • Carr, P, Ewens, C, Dai, J et al. 2014, 'Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation', Biochemical Journal, vol. 463, no. 3, pp. 393-403.
  • Tokuriki, N & Jackson, C 2014, 'Enzyme dynamics and engineering: one step at a time', Chemistry and Biology, vol. 21, no. 10, pp. 1259-1260.
  • Carruthers, T, Carr, P, Loh, C et al 2014, 'Iron(III) located in the dinuclear metallo-beta-lactamase IMP-1 by pseudocontact shifts', Angewandte Chemie International Edition, vol. 53, no. 51, pp. 14269-14272.
  • Jackson, C, Liu, J, Carr, P et al. 2013, 'Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 25, pp. 10177-10182.
  • Zhang, W, Otting, G & Jackson, C 2013, 'Protein engineering with unnatural amino acids', Current Opinion in Structural Biology, vol. 23, no. 4, pp. 581-587.
  • Noor, S, Taylor, M, Russell, R et al 2012, 'Intramolecular epistasis and the evolution of a new enzymatic function', PLOS ONE (Public Library of Science), vol. 7, no. 6, pp. e39822-e39822.
  • Perriman, A, Weik, M, Gallat, F et al 2012, 'A polymer surfactant corona dynamically replaces water in solvent-free protein liquids and ensures macromolecular flexibility and activity', Journal of the American Chemical Society, vol. 134, no. 32, pp. 13168-13171.
  • Afriat-Jurnou, L, Jackson, C & Tawfik, D 2012, 'Reconstructing a missing Link in the Evolution of a Recently Diverged Phosphotriesterase by Active-Site Loop Remodeling', Biochemistry, vol. 51, no. 31, pp. 6047-6055.
  • Tokuriki, N, Jackson, C, Afriat-Jurnou, L et al. 2012, 'Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme', Nature Communications, vol. 3, no. 12, pp. 1257-1257.
  • Coppin, C, Jackson, C, Sutherland, T et al 2012, 'Testing the evolvability of an insect carboxylesterase for the detoxification of synthetic pyrethroid insecticides', Insect Biochemistry and Molecular Biology, vol. 42, no. 5, pp. 343-352.
  • Russell, R, Scott, C, Jackson, C et al 2011, 'The evolution of new enzyme function: lessons from xenobiotic metabolizing bacteria versus insecticide-resistant insects', Evolutionary Applications, vol. 4, no. 2, pp. 225-248.
  • Ugwumba, I, Ozawa, K, Xu, Z et al. 2011, 'Improving a natural enzyme activity through incorporation of unnatural amino acids', Journal of the American Chemical Society, vol. 133, no. 2, pp. 326-333.
  • Brittain, D, Pandey, R, Kumari, K et al 2011, 'Competing SN2 and E2 reaction pathways for hexachlorocyclohexane degradation in the gas phase, solution and enzymes', Chemical Communications, vol. 47, no. 3, pp. 976-978.
  • Fraser, J & Jackson, C 2011, 'Mining electron density for functionally relevant protein polysterism in crystal structures', Cellular and Molecular Life Sciences, vol. 68, no. 11, pp. 1829-1841.
  • Sharma, P, Pandey, R, Kumari, K et al 2011, 'Kinetic and Sequence-Structure-Function Analysis of Known LinA Variants with Different Hexachlorocyclohexane Isomers', PLOS ONE (Public Library of Science), vol. 6, no. 9, pp. e25128-e25128.
  • Taylor, M, Jackson, C, Tattersall, D et al 2010, 'Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyze aflatoxin degradation', Molecular Microbiology, vol. 78, no. 3, pp. 561-575.
  • Khersonsky, O, Rothlisberger, D, Dym, O et al 2010, 'Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series', Journal of Molecular Biology, vol. 396, no. 4, pp. 1025-1042.
  • Jackson, C, Gillam, E & Ollis, D 2010, 'Directed evolution of enzymes', in Lew Mander and Hung-Wen (Ben) Liu (ed.), Comprehensive Natural Products Chemistry II: Chemistry and Biology, Elsevier, Oxford, pp. 723-749.
  • Jackson, C, Oakeshott, J, Sanchez-Hernadez, J et al 2010, 'Caboxylesterases in the metabolism and toxicity of pesticides', in Satoh T., Gupta R.C. (ed.), Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, John Wiley & Sons Inc, Hoboken USA, pp. 57-75.
  • Lal, R, Pandey, G, Sharma, P et al 2010, 'Biochemistry of microbial degradation of hexachlorocyclohexane and prospects for bioremediation', Microbiology and Molecular Biology Reviews, vol. 74, no. 1, pp. 58-80.
  • Gresham, C, Rosenbaum, C, Gaspari, R et al 2010, 'Kinetics and efficacy of an organophosphorus hydrolase in a rodent model of methyl-parathion poisoning', Academic Emergency Medicine, vol. 17, no. 7, pp. 736-740.
  • Scott, C, Russell, R, Coppin, C et al 2010, Enzymes and methods for degrading S-triazines and diazines.
  • Khurana, J, Jackson, C, Scott, C et al 2010, Enzymes and methods for hydrolysing a phenylureas, carbamates and organophosphates.
  • Scott, C, Jackson, C, Coppin, C et al 2009, 'Catalytic improvement and evolution of atrazine chlorohydrolase', Applied and Environmental Microbiology, vol. 75, no. 7, pp. 2184-2191.
  • Scott, C, Jackson, C, Russell, R et al 2009, Enzymes and methods for degrading chlorinated S-triazines.
  • Weston, D & Jackson, C 2009, 'Use of engineered enzymes to identify organophosphate and pyrethroid-related toxicity in toxicity identification evaluations', Environmental Science and Technology, vol. 43, no. 14, pp. 5514-5520.
  • Scott, C, Pandey, G, Hartley, C et al 2008, 'The enzymatic basis for pesticide bioremediation', Indian Journal of Microbiology, vol. 48, no. 1, pp. 65-79.
  • Jackson, C, Hadler, K, Carr, P et al. 2008, 'Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, vol. 64, no. 8, pp. 681-685.
  • Hadler, K, Tanifum, E, Yip, S et al. 2008, 'Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes', Journal of the American Chemical Society, vol. 130, no. 43, pp. 14129-14138.
  • Jackson, C, Foo, J, Kim, H et al. 2008, 'In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase*', Journal of Molecular Biology, vol. 375, no. 5, pp. 1189-1196.
  • Jackson, C, Carr, P, Liu, J et al. 2007, 'The structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes', Journal of Molecular Biology, vol. 367, no. 4, pp. 1047-1062.
  • Ely, F, Foo, J, Jackson, C et al 2007, 'Enzymatic bioremediation: organophosphate degradation by binuclear metallo-hydrolases', Current Topics in Biochemical Research, vol. 9, no. 2, pp. 63-78.
  • Jackson, C, Carr, P, Kim, H et al. 2006, 'Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site', Biochemical Journal, vol. 397, no. 3, pp. 501-508.
  • Jackson, C, Carr, P, Kim, H et al. 2006, 'The purification, crystallization and preliminary diffraction of a glycerophosphodiesterase from Enterobacter aerogenes', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, vol. 62, no. 7, pp. 659-661.
  • Yu McLoughlin, S, Jackson, C, Liu, J et al 2005, 'Increased expression of a bacterial phosphotriesterase in Escherichia coli through directed evolution', Protein Expression and Purification, vol. 41, no. 2, pp. 433-440.
  • Jackson, C, Kim, H, Carr, P et al. 2005, 'The structure of an enzyme-product complex reveals the critical role of a terminal hydroxide nucleophile in the bacterial phosphotriesterase mechanism', Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics, vol. 1752, no. 1, pp. 56-64.
  • Jackson, C, Liu, J, Coote, M et al 2005, 'The effects of substrate orientation on the mechanism of a phosphotriesterase', Organic and Biomolecular Chemistry, vol. 3, no. 24, pp. 4343-4350.
  • Yu McLoughlin, S, Jackson, C, Liu, J et al 2004, 'Growth of Escherichia coli coexpressing phosphotriesterase and glycerophosphodiester phosphodiesterase, using paraoxon as the sole phosphorus source', Applied and Environmental Microbiology, vol. 70, no. 1, pp. 404-412.